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Promethazine sulfoxide is a metabolite of the histamine H1 receptor antagonist Promethazine (HY-B1296) It is formed from promethazine by the cytochrome P450 (CYP) isoform CYP2D6
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(Cyclohexanecarbonyl)-L-leucine is a cyclohexanecarbonyl-protected derivative of the amino acid L-leucine supplied as a research reagent. It is provided as a white to off-white solid with defined purity and storage recommendations for laboratory use.
Sulindac sulfone (CAS 59864-04-9) is a metabolite of the NSAID sulindac and has been investigated for its effects on colorectal cancer models It modulates cellular signaling by decreasing -catenin pro-caspase 3 cyclin D1 and PPAR levels in SW480 cells and reduces TCF-mediated transcription in a dose-dependent manner In vitro sulindac sulfone inhibits PGE2 production in HCA-7 cells (IC50 360 mmol/L) and decreases colony formation in HCA-7 and HCT-116 cells (EC50 50 mmol/L) In vivo it lowers tumor incidence in the AOM-induced colorectal cancer rat model Clinically it has led to regression of rectal polyps in familial adenomatous polyposis patients Sulindac sulfone is utilized in research focused on colorectal cancer chemoprevention and -catenin pathway modulation
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Ertapenem sodium salt (CAS 153832-38-3) is a small-molecule inhibitor targeting bacterial penicillin-binding proteins (PBPs) particularly PBPs 2 and 3 It is designed to disrupt bacterial cell wall synthesis thereby inhibiting bacterial growth Ertapenem sodium salt exerts its biological activity primarily through binding to PBPs and interfering with cell wall synthesis In in vitro studies ertapenem sodium salt demonstrates broad-spectrum inhibitory activity with minimal inhibitory concentrations (MIC90) generally below 1 mg/L against Enterobacteriaceae isolates and MIC90 ranging between 1 4 mg/L against various Bacteroides fragilis strains Based on these pharmacological properties ertapenem sodium salt holds research potential in microbiological studies and drug susceptibility screenings focused on resistant bacterial pathogens
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Fluorescein-5-isothiocyanate (FITC Fluorescein isothiocyanate isomer I 5-FITC) is a fluorescent probe capable of being conjugated to tissue and proteins
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Sonidegib metabolite M48 (2-methyl-3-[4-(trifluoromethoxy)phenyl]benzoic acid) is the primary circulating metabolite of sonidegib, supplied as a research-grade reference standard for pharmacokinetic, metabolic, and analytical studies.
For research use only; not for human or clinical use.
High purity: 98.0%.
White to off-white solid, stable under recommended storage.
Comprehensive analytical data available (COA, HNMR, LC-MS).
Recommended storage: room temperature (solid) for up to 3 years; in solvent: -80°C for 2 years, -20°C for 1 year.
Suitable as a reference standard for PK and metabolism studies.
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